NCT01878279
Completed
Not Applicable
Longitudinal Study to Evaluate the Frequency of HSV-1 Oral Reactivation in Children in Dar es Salaam, Tanzania
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HSV-1
- Sponsor
- Dartmouth-Hitchcock Medical Center
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- HSV detection rate
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
In the proposed study, the investigators will carry out novel research to evaluate both symptomatic and asymptomatic daily oral herpes simplex virus (HSV) shedding rates and copy number in children with and without HIV.
Study Objectives:
-
To evaluate the frequency of oral HSV reactivation in HIV-infected and uninfected children
Secondary Objectives:
-
To determine the acceptability of performing daily oral swabs in children age 3-12
Investigators
Eligibility Criteria
Inclusion Criteria
- •age \> 3 and ≤12 years old
- •parental/guardian consent and children's assent must be obtained and participants and parent/guardian must be able to comply with study procedures
- •For HIV-infected group: Positive HIV serology by either ELISA x 2, ELISA + WB or PCR testing
Exclusion Criteria
- •age \<3 and \> 12 years old
- •Acute illness which by opinion of the investigator makes enrollment in the trial unfeasible (including active tuberculosis, malaria or other opportunistic infection requiring treatment)
- •co-enrollment in other therapeutic/intervention trials (observational trial enrollment is permitted).
- •Stable co-administration of other medications is permitted (e.g. bactrim)
- •For HIV-infected children; receiving or eligible for antiretroviral (ART) therapy by local standards
Outcomes
Primary Outcomes
HSV detection rate
Time Frame: 14 days
Secondary Outcomes
- HSV copy number(14 days)
Study Sites (1)
Loading locations...
Similar Trials
Terminated
Not Applicable
INSIGHT-AHP: A Study to Characterize the Prevalence of Acute Hepatic Porphyria (AHP) in Patients With Clinical Presentation and History Consistent With AHPAcute Hepatic PorphyriaHepatic PorphyriasAcute Intermittent Porphyria (AIP)Hereditary Coproporphyria (HCP)Variegate Porphyria (VP)ALA Dehydratase Deficient Porphyria (ADP)Porphyria AcuteNCT03547297Alnylam Pharmaceuticals212
Completed
Not Applicable
Observational Study to Investigate Resistant Hypertension Prevalence in Korean General HospitalsHypertensionNCT01753206Handok Inc.1,579
Completed
Not Applicable
Humoral and Cellular Immunity Against SARS-COV-2 Vaccine in HIV-infected Patients ImmunosuppressedSARS-CoV-2 RNA VaccinesHIV InfectionNCT05633927Hospitales Universitarios Virgen del Rocío48
Enrolling By Invitation
Not Applicable
Epidemiological and Clinical Characteristics of Hospitalized Patients Under 5 Years Old With RSV Infection in Central China, WuhanRSV InfectionNCT05767294Tongji Hospital10,000
Completed
Phase 3
Detection and Characterisation of Varicella Zoster Virus From Dermal Lesions of Chickenpox-infected PatientsVaricellaNCT00127608GlaxoSmithKline36