Randomised controlled trial of remote ischaemic pre-conditioning to reduce dialysis induced myocardial stunning in haemodialysis patients
Not Applicable
Completed
- Conditions
- Cardiovascular, Renal and UrogenitalCirculatory SystemCardiovascular disease
- Registration Number
- ISRCTN22392984
- Lead Sponsor
- Derby Hospital NHS Foundation Trust (United Kingdom)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
1. Patients having haemodialysis treatment at least 3 times per week at the Royal Derby Hospital
2. Male or female
3. Lower Age Limit 16 years
Exclusion Criteria
1. Not meeting inclusion criteria
2. Exposure to haemodialysis for <90 days prior to recruitment
3. Severe heart failure (New York Heart Association grade IV)
4. Cardiac transplant recipients
5. Mental incapacity to consent
6. Declined to participate
7. Taking cyclosporin
8. Taking ATP-sensitive potassium channel opening or blocking drugs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Regional wall motion abnormalities on 2D-echo<br>2. Timepoint(s): Within 4 hours of the stimulus or sham-stimulus
- Secondary Outcome Measures
Name Time Method 1. Change in haemodynamic variables after:<br>1.1. Intervention visit <br>1.2. First follow-up visit<br>1.3. Final visit<br>2. Frequency of intradialytic hypotension after:<br>2.1. Intervention visit <br>2.2. First follow-up visit<br>2.3. Final visit<br>3. Regional wall motion abnormalities on 2D-echo after:<br>3.1. First follow-up visit<br>3.2. Final visit<br>4. Troponin-T, Plasma IL-6 and N-Type proBNP after:<br>4.1. Intervention visit <br>4.2. First follow-up visit<br>4.3. Final visit