Observational, correlational study aimed to identify healthy elderly subjects with Alzheimer pathology more efficiently
- Conditions
- eurodegenerative disordersAlzheimer's diseaseDementia
- Registration Number
- NL-OMON44173
- Lead Sponsor
- Centre for Human Drug Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
1. Males and females, aged 65 and older (inclusive);
2. Willing and able to perform the cognitive tests, as evidenced by performance on the training session of the cognitive tests;
3. Willing and able to give written informed consent and to comply with the study procedures.
1. Legal incapacity or inability to understand or comply with the requirements of the study;
2. Evidence of cognitive deterioration, as indicated by a diagnosis of a cognitive disorder (including but not limited to MCI, Alzheimer*s disease, Lewy Body Dementia, Fronto-temporal Dementia);
3. History or symptoms of significant psychiatric disease in the past 3 years (including but not limited to clinical depression, schizophrenia);
4. A Mini Mental State Examination (MMSE) score of *24;
5. A Geriatric Depression Scale * 15 (GDS) score of *6;
6. Presence of drug abuse, or positive urine drug screen (UDS) at screening or occasion;
7. Presence of severe alcohol abuse (daily alcohol consumption exceeding 2 standard drinks per day on average for females or exceeding 3 standard drinks per day on average for males (1 standard drink = 10 grams of alcohol)), or a positive breath alcohol test at screening or occasion;
8. Any contradictions for a lumbar puncture as judged by the principal investigator.
9. Any other reason that it is not safe or ethical to allow a subject to participate in the study in the opinion of the investigator.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method