Study on New Strategies for Hepatitis B Virus Immunization
- Conditions
- Vaccine Reaction
- Registration Number
- NCT06515938
- Lead Sponsor
- Wu Jiang
- Brief Summary
To investigate the immunogenicity of HB vaccine with different series among primary immune adults aged 25-55, to assess potential alternative approaches for HB immunization.
- Detailed Description
By comparing the immunization effect of hepatitis B vaccine with other different types of hepatitis B vaccines using seris procedure, information on the immunization effect of 60 micrograms of hepatitis B vaccine in adults was obtained, which will provide a scientific basis for the development of a rapid immunization procedure for adults with large doses of hepatitis B vaccine and for the improvement of the immunization strategy for hepatitis B in adults.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1169
- aged 25-55 years
- negative for HBsAg,anti-HBs, and anti-HBc without prior HBV or HAV vaccination
- a history of vaccine component allergies
- autoimmune diseases
- immunodeficiency
- vaccinations received within the past month
- acute illnesses within the past week
- fever (axillary temperature exceeding 38°C) within the past three days
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Anti-HBs at the second month after the final injection of each arm Titers of hepatitis B virus surface antibody
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Huaibei District Center for Disease Control and Prevention
🇨🇳Huaibei, Anhui, China
Xuanhua District Center for Disease Control and Prevention
🇨🇳Xuanhua, Hebei, China
Huaibei District Center for Disease Control and Prevention🇨🇳Huaibei, Anhui, China