Neuroplasticity of Multisensory Cortical Areas Induced by Computerized Musical Training, Across the Life Span: a Translational Approach
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Change in cortical connectivity as measured via EEG
研究概览
简要总结
Exploiting recent methodological advancements, several neuroimaging studies suggested that multisensory integration emerges from a dynamic interplay of distributed regions operating in large-scale networks. Nonetheless, the cortical structures and neuronal networks underlying the development of multisensory perception and plasticity, throughout the life span, have not yet been studied in detail. A special case of multisensory training is musical training, which utilizes stimulus' structural complexity, as well as the emotional drive that music is generating to the subjects, in order to induce augmented neuroplastic effects.
Retaining the extensive neuroplastic characteristics of music training, MUSICPLAST will develop, investigate and deliver a computer provided multisensory training protocol that aims to induce neuroplastic changes in frontotemporal cortical areas. More specifically, the goal of the proposed project is threefold: (a) The in-depth understanding and modeling of the developmental trajectory of the cortical networks underlying multisensory perception, (b) the modeling of the developmental trajectory of the cortical networks underlying multisensory plasticity throughout the life span of healthy subjects; and (c) the translation of this model in a computer provided multisensory training intervention protocol, which will cause beneficial neuroplastic changes in pathological populations. Electroencephalographic, behavioral and neuropsychological measurements, and advanced data analysis procedures, pre- and post the training application are going to be employed in order to evaluate the resulting neuroplasticity holistically. The proposed protocol will also be translated into an applied intervention for 2 groups of pathological population, for which there are strong evidence that a multisensory cognitive training based on music may provide beneficial neuroplastic changes: elderlies suffering from mild cognitive Impairment and adolescents with dyslexia.
The project is performed in the Laboratory of Medical Physics of the Aristotle University of Thessaloniki. It takes advantage of the extensive background of the laboratory in music and neuroscience, in multisensory perception and in applications that translate basic neuroscientific knowledge into computer based interventions for young adults and elderlies, building up a solid neuroscientific ground on which multidisciplinary characteristics of the project stand.
详细描述
Goals and research questions
The first goal of MUSICPLAST is to explore in-depth the development of audiovisual perception in the healthy human brain describing in detail the corresponding cortical networks involved. High density EEG measurements (128 channels) are going to be employed for the realization of this goal following a stimulation protocol which incorporates auditory, visual and audiovisual correspondences in a unified multisensory oddball paradigm. Behavioral and neuropsychological evaluation of the multisensory perceptual abilities of the subjects will be performed in order to achieve a holistic understanding of the phenomenon. The within subjects comparison of the different conditions will reveal the corresponding network, while the between subjects, its developmental trajectory. The hypothesis of this experiment, is that the network underlying audiovisual perception will be comprised from cortical areas connecting widespread regions including dorsolateral regions of the frontal cortex. Regarding its development, and based on the fact that behaviorally multisensory integration continues to improve in healthy aging, it is hypothesized that the network will be reorganized showing enhanced density and efficiency as the age progresses.
The second goal of MUSICPLAST is to explore in-depth the plasticity of the cortical network underlying audiovisual perception in the healthy human brain, as induced via a computer provided short-term musical reading training. Pre- and post- training high-density EEG, behavioral and neuropsychological measurements are going to be employed for the realization of this goal following the same stimulation paradigm as for the previously mentioned goal. The hypothesis of this experiment, is that the network underlying audiovisual perception will be reorganized showing enhanced global density and efficiency, greater connectivity between temporal and frontopolar regions and a gradual decline of the amount of plasticity as a result of the age increase.
The third goal of MUSICPLAST is to evaluate the effectiveness of the proposed computerized music reading training protocol as a tool that will promote beneficial neuroplastic changes in pathological populations and specifically, dyslectic adolescents and elderlies. Pre- and post- training high-density EEG, behavioral and neuropsychological measurements are going to be employed for the realization of this goal following the same stimulation paradigm as for the previously mentioned goals. The hypothesis of this experiment, is that the network underlying audiovisual perception will be beneficially reorganized due to the training showing enhanced global density and efficiency, greater connectivity between temporal and frontopolar regions and that these changes will be accompanied from improvement in the corresponding behavioral and neuropsychological evaluation.
Research design and methodology Participants
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
盲法说明
The participant is not aware of the group (intervention or control) in which s/he belongs.
入排标准
- 年龄范围
- 12 Years 至 100 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •13 - 18 years of age
- •normal or corrected-to-normal hearing and vision
- •Diagnosed dyslexia
排除标准
- •any other than dyslexia, diagnosed neurological, mental, developmental or psychiatric disorder
- •(ii) unrecovered neurological disorders (i.e., stroke, traumatic brain injury),
- •(iii) unstable medication within the last 3 months,
- •(iv) severe physical disorder, and
- •(v) concurrent participation in another relevant study.
- •Group of Adolescent controls
- •Inclusion Criteria:
- •13 - 18 years of age
- •normal or corrected-to-normal hearing and vision
- •Exclusion Criteria:
- •(I) any diagnosed neurological, mental, developmental or psychiatric disorder
- •(ii) unrecovered neurological disorders (i.e., stroke, traumatic brain injury),
- •(iii) unstable medication within the last 3 months,
- •(iv) severe physical disorder, and
- •(v) concurrent participation in another relevant study.
- •Group of Young Adults
- •Inclusion Criteria:
- •18 - 35 years of age
- •normal or corrected-to-normal hearing and vision
- •Exclusion Criteria:
- •(I) any diagnosed neurological, mental, developmental or psychiatric disorder
- •(ii) unrecovered neurological disorders (i.e., stroke, traumatic brain injury),
- •(iii) unstable medication within the last 3 months,
- •(iv) severe physical disorder, and
- •(v) concurrent participation in another relevant study.
- •Group of Seniors
- •Inclusion Criteria:
- •65 - 100 years of age
- •normal or corrected-to-normal hearing and vision
- •normal score in a neuropsychological screening procedure which regards cognitive functionality
- •Exclusion Criteria:
- •(i) unrecovered neurological disorders (i.e., stroke, traumatic brain injury),
- •(ii) severe depression or psychological disorder,
- •(iii) unstable medication within the last 3 months,
- •(iv) severe physical disorder, and
- •(v) concurrent participation in another relevant study.
研究组 & 干预措施
Adolescents with dyslexia
MusicPlast training
干预措施: MusicPlast (Behavioral)
Adolescents without dyslexia
MusicPlast training
干预措施: MusicPlast (Behavioral)
Young Adults
MusicPlast training
干预措施: MusicPlast (Behavioral)
Young Adults Control
MusicPlast Control, in a similar design as MusicPlast
干预措施: MusicPlast Control (Behavioral)
Seniors
MusicPlast training
干预措施: MusicPlast (Behavioral)
结局指标
主要结局
Change in cortical connectivity as measured via EEG
时间窗: 1 month
Changes in cortical connectivity caused via the training. Change is defined as statistical significance in the t-test comparison of the Transfer Entropy estimated from the cortical activity, as reconstructed via LORETA algorithm on the basis of high density EEG recordings, before compared to after the training.
Change in current density strength of the cortical activity as measured via EEG
时间窗: 1 month
Changes in cortical activity strength caused via the training. Change is defined as statistical significance in the t-test comparison of the current density strength as reconstructed via Low Resolution Electromagnetic Tomography (LORETA) algorithm on the basis of high density EEG recordings, before compared to after the training
次要结局
- Change in cognitive functionality(1 month)
- Change in audiovisual integration functionality(1 month)
研究者
Panos Bamidis
Associate Professor
Aristotle University Of Thessaloniki