The role of innate immunity and regulatory T cells in the development of immune tolerance in early life.
Completed
- Conditions
- allergy10001708
- Registration Number
- NL-OMON33767
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
- antanatal diagnosed birthdefect such as schizis, duodenal atresia or orthopedic problems
- uncomplicated pregnancy and delivery
- birth planned in UMCU/WKZ
- a term delivery
- availability of cordblood
- one or more times surgery in the first year of life
Exclusion Criteria
Complications during pregnancy (HELPP, infection)
Use of immune modulating medication during pregnancy
Smoking during pregnancy
Perinatal complications
- Prematurity (<36 weeks) or dysmaturity (birthweight - Use of antibiotics by the mother in the two weeks before delivery
- Use of antibiotics by the child in the first two weeks of life
- Immunological disorders such as VCF, DiGeorge
- Chromosomal disorder
- Perinatal infection
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Development in time of number, phenotype and function of several subsets of<br /><br>mononuclear cells with special attention for T regulatory cells. Levels and<br /><br>effect of immune modulating factors such as adenosine, PGE2 and innate stimuli<br /><br>on the function of immune cells over time. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>