Evaluation of the Effect of Megestrol Acetate plus Celecoxib in Combination versus Megestrol Acetate alone in Cachexia Induced by Gastrointestinal Cancers

Mazandaran University of Medical Scienses0 个研究点目标入组 80 人开始时间: 待定最近更新: 2018年2月22日

适应症

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•Age of more than 18 y; Confirmed diagnosis of gastroesophageal or colorectal cancer in any stage; Hope for survival of at least 4 month; More than 5% weight loss in the past 3 to 6 month or more than 5% weight loss in comparison to the weight before disease or a body weight less than 5% of ideal body weight or a BMI (Body Mass Index) of less than 20; Palliative treatments or chemotherapy is allowed
•Exclusion criteria: Mechanical obstruction in alimentary tract; Any treatment which induce weight gain like glucocorticoids; Diagnosis of diabetes mellitus with concomitant insulin therapy; Uncompensated cardiac failure with ejection fraction of less than 30% or with New York Heart Association function class of 3 or 4; Uncontrolled Hypertention with systolic blood pressure greater than140 mmHg or diastolic blood pressure greater than 90 mmHg; History of myocardial infarction; History of unstable angina; History of Cerebro-vascular accidents; Uncontrolled cardiac dysrhythmias; Inflammatory bowel disease; Gastrointestinal ulcers or history of GI bleedings

发起方

Mazandaran University of Medical Scienses