Detection no Invasive of a Silent Myocardial Ischemia

Terminated

• Conditions: Type 2 Diabetes; Silent Myocardial Ischemia

• Registration Number: NCT02885428
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The pathophysiological features of myocardial diabetic subject combined with cardiac autonomic neuropathy were behind the quietness of myocardial ischemia, known as silent myocardial ischemia (IMS). These patients have the risk to remain asymptomatic until the sudden onset of a myocardial infarction, or even sudden death.

That is why the investigators want to evaluate the contribution of non-invasive tools to stand in the diagnosis of IMS patients with diabetes type 2, asymptomatic heart on map: Technical myocardial speckle tracking in studying strains overall average left ventricular (longitudinal, circumferential and radial) measured in 2D and 3D at rest, compared to stress echocardiography with dobutamine (ESD)

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04-15
• Primary Completion: 2015-04-15
• Study First Submitted: 2016-08-26
• Study First Submitted QC: 2016-08-26
• Study First Posted: 2016-08-31
• Study Completion: 2018-04-17
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-10
• Last Update Posted: 2022-10-13

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 47

Inclusion Criteria

• With at least two cardiovascular risk factors including: hypertension, dyslipidemia, smoking active or interrupted for less than 3 years, family history (relatives of the 1st degree) Accident major CV before 60.
• Or whatever the level of risk factors: peripheral artery disease and / or carotid atherosclerosis, or proteinuria

Exclusion Criteria

• Valvular heart disease (severe to moderate valvular ) , hypertrophic , dilated , chronic lung
• History of cardiotoxic chemotherapy
• Atrioventricular blocks of degree
• Asthma
• Recent stroke within a month
• Bilateral carotid stenosis tight
• Glaucoma untreated narrow angle
• Subject to exclusion period (determined by a previous study or in progress)
• Inability to give informed about information
• patient under judicial protection
• patient guardianship or curatorship
• Current pregnancy (women of childbearing age )
• Breastfeeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diagnostic of the silent myocardial ischemia	80 minutes

Trial Locations

Locations (1)

Les Hôpitaux Universitaires; 🇫🇷 Strasbourg, France