Predicting the effect of transcranial direct current stimulation on brain excitability
- Conditions
- CVAStroke10007963
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Healthy
Age 18-55 yr
Intact skin on the scalp
Exclusion Criteria
History of neurological or psychiatric disorders
Implants or metal parts in the head
Use of psychoactive drugs in the last month
Pregnancy
Left-handedness
Skin disease on the scalp, such as eczema
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>MEP-amplitude ratio: Measure for brain excitability. The height of the MEP<br /><br>amplitudes will be measured at a constant stimulation intensity. The grand<br /><br>average after TDCS will be divided by the average before TDCS. APLM (latency):<br /><br>Difference in MEP latencies between TMS pulses with an anterior-posterior<br /><br>current direction and lateral-medial current direction. Denoted in<br /><br>milliseconds. BDNF (val66met genotype): non-carrier or met-carrier. Derived<br /><br>from genotyping saliva samples. </p><br>
- Secondary Outcome Measures
Name Time Method <p>MAIN1: The MEP-ratio of the first anodal session minus the MEP-ratio of the<br /><br>second placebo session i.e. the main effect in the first measurement pair.<br /><br>MAIN2: The MEP-ratio of the second anodal session minus the MEP-ratio of the<br /><br>second placebo session i.e. the main effect in the second measurement pair.<br /><br>IO-curve ratio: Alternative measure of brain excitability. he height of the MEP<br /><br>amplitudes at a range of stimulation intensities (the input output curve). The<br /><br>average area under the curve after TDCS will be divided by the average before<br /><br>TDCS.</p><br>