A Novel Positron Emission Tomography (PET) Approach to Measuring Myocardial Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Myocardial Fatty Acid Uptake Rate
研究概览
简要总结
Studies of myocardial fuel selection using a novel palmitate-based PET probe
详细描述
A novel Positron Emission Tomography (PET) probe, 16- 18-F-fluoro-4-thiapalmitate, will be used to evaluate myocardial atty acid uptake. Studies will be done in humans with type 2 diabetes mellitus, and in controls. Studies will take place on 2 separate days, under fasting conditions and under insulin clamp conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI<25 kg/m2
- •normal glucose tolerance by 75g oral glucose tolerance test
- •Type 2 diabetes mellitus:
- •BMI >25 kg/m2
- •previously diagnosed type 2 diabetes mellitus
- •on oral and/or injected insulin treatment.
排除标准
- •*Use of any chronic medications
- •Type 2 diabetes mellitus
- •known microvascular disease
- •known coronary or other macro vascular disease
- •use of PPARgamma class antidiabetic agents within 6 months
研究组 & 干预措施
Saline
Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).
干预措施: thiapalmitate tracer (Drug)
Saline
Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).
干预措施: Saline (Drug)
Insulin Clamp
Studies will be performed on a separate day under fasting conditions, using an insulin infusion to achieve steady state insulin/glucose clamp conditions. Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).
干预措施: thiapalmitate tracer (Drug)
Insulin Clamp
Studies will be performed on a separate day under fasting conditions, using an insulin infusion to achieve steady state insulin/glucose clamp conditions. Studies will be performed on one day under fasting conditions, using a saline infusion. All subjects will receive infusions of radiolabeled acetate and radiolabeled thiapalmitate tracer (16-18-F-fluoro-4-thiapalmitate).
干预措施: Insulin (Drug)
结局指标
主要结局
Myocardial Fatty Acid Uptake Rate
时间窗: 4 Hours
PET measure of fatty acid uptake rate
次要结局
- Myocardial Perfusion Rate(4 Hours)
- Myocardial Oxidation Rate(4 Hours)