Investigation of PEEP-ZEEP pulmonary secretion clearance maneuver and its early effects on cardiac and respiratory systems

Not Applicable

• Conditions: Ventilator-associated pneumonia, artificial respiration, physical therapy modalities; C01.539.248.500; E02.041.625; E02.779

• Registration Number: RBR-223xv8
• Lead Sponsor: niversidade Federal do Triângulo Mineiro

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-08-16
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients with pulmonary secretion on mechanical invasive ventilation; hemodynamically stable (MBP higher than 65 mmHg); PEEP lower or equal than 10 cmH2O; oxygen inspiratory fraction lower or equal than 0,4; peripheral oxygen saturation higher than 90%.

Exclusion Criteria

Intracranial hypertension; cor pulmonale; pulmonary hypertension; pregnancy; pneumothorax not drained; rib fractures; thoracic drain tube.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean difference of expiratory flow bias (peak expiratory flow minus peak inspiratory flow) between PEEP-ZEEP maneuver applied in pressure control vs. volume control mode of at least 15 L/min.;Mean difference of expiratory flow bias (peak expiratory flow minus peak inspiratory flow) between PEEP-ZEEP maneuver applied with manual thoracic compression vs. without compression of at least 5 L/min.

Secondary Outcome Measures

Name	Time	Method
Equivalence on hemodynamics and respiratory mechanic during the 30-minute-interval after PEEP-ZEEP performance in volume control vs. pressure control, and after PEEP-ZEEP with thoracic compression vs no compression.