Enhancing muscle healing using platelet-rich plasma (PRP) injectio

Completed

Conditions: Muscle injury
Musculoskeletal Diseases
Muscle strain

Registration Number: ISRCTN66528592

Lead Sponsor: niversity Malaya Medical Centre (Malaysia)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 30

Inclusion Criteria

1. 18 years old and above
2. Acute muscle injury (less than 1 week)
3. Able to understand study protocol and informed consent

Exclusion Criteria

1. Received any form of injection therapy
2. Using non-steroidal anti-inflammatory drugs (NSAIDs) within 1 week prior to randomisation
3. Unable to fulfill follow-up schedule
4. Significant cardiovascular, renal, hepatic disease, malignancy, history of anemia or previous muscle surgery

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Duration to full recovery (return-to-play)<br>Criteria for RTP:<br>1.1. Muscle strength: at or near pre-injury levels or symmetrical with unaffected site<br>1.2. Range of motion: at or near pre-injury levels or symmetrical with unaffected site<br>1.3. Tenderness: injury site should be non-tender<br>1.4. Inflammation or swelling: no swelling or inflammation<br><br>Outcomes are measured on a weekly basis until full recovery of the end of week 16

Secondary Outcome Measures

Name	Time	Method
1. Level of platelets - blood and PRP<br>2. Level of growth factors in PRP<br>2.1. Insulin-like growth factor (IGF-1)<br>2.2. Transforming growth factor (TGF)-beta<br>2.3. Basic fibroblast growth factor (FGF)<br>2.4. Platelet-derived growth factor (PDGF)<br>3. Isokinetic muscle strength<br>4. Brief pain inventory - Short form (BPI-SF)<br><br>Outcomes are measured on a weekly basis until full recovery of the end of week 16