The effect of Platelet Rich- plasma on facial aging

Not Applicable

• Conditions: Facial ageing; G13.750.804

• Registration Number: RBR-3n9wxw
• Lead Sponsor: Centro de Hematologia e Hemoterapia - HEMOCENTRO

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-09-04
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Healthy volunteers; women; non-smokers; age between 40 and 65 years; Glogau grade II or III photoaging; Fitzpatrick phototype I-IV

Exclusion Criteria

Volunteers smoking; history of alcohol or drug abuse; pregnant or in the puerperium; facial aesthetics with absorbent material (hyaluronic acid), laser use in the last year, use of retinoic acid, application of botox or filling and surgical procedures; patients with a history of photosensitivity and of keloid or hypertrophic scar; patients with lesions of infected or inflamed skin on the face in the last year; underlying diseases such as uncontrolled hypertension, liver disease, renal, haematological, inflammatory, rheumatologic, diabetes; patients who have or have had dysplasias;

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
It is expected to find an amplified rejuvenating effect on PRP by increasing the thickness of the dermis and epidermis;A significant increase in dermis thickness was observed in both groups (PRP vs Serum) from 1.27 mm (standard deviation of 0.52) to 1.59 mm (standard deviation of 0.65) post PRP (p equals 0.0576), for example.

Secondary Outcome Measures

Name	Time	Method
Evaluate such improvement through visual techniques by VISIA equipment;<br>Through the SHG method, it is expected to find increased collagen in patients treated with PRP.;By the SHG methods, of the 19 patients, there was an expressive but not significant improvement of the collagen fibers increase by SHG microscopy with PRP application and a significant reduction of collagen by the side applied the serum.<br>Regarding the Visia analysis, we observed a decrease in the number of wrinkles in the hemiface treated with PRP (pre 3.9, IQR 2.5 - 8.6, post 3.6, IQR 1.3 - 7.5) but not (pre 4.2, IQR 2.2 - 8.3 and post 5.4, IQR 1.4 - 7.3) (p equals to 0.25).<br><br>A study recruited 88 women, but only 21 began the study and 19 concluded.