Effects of Platelet Rich Plasma in Treatment of patients with Long Bones Non-unions
Not Applicable
- Conditions
- onunion of fracture.Nonunion of fracture [pseudarthrosis]
- Registration Number
- IRCT201208262445N1
- Lead Sponsor
- Trauma Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
Age>18 years; long bone non-unions (Femur, Tibia, Fibula, Humerus, Ulna, Radius) with duration of more than 6 months
Exclusion criteria: Age<18 years; infectious non-unions; vascular injuries; large skin defects of fracture site; musculoskeletal disorders; malignancies; pathological fractures (tumors, metabolic osteopenia); active autoimmune disorders; large bone defects; platelet count <100,000 per micro-liter; treatment with growth factors within the previous years; treatment with steroids and NSAIDs during the previous year
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical cure rate. Timepoint: Postoperaive days 45, 90, 135, 180, 225, 270. Method of measurement: Physical examination.;Radiological cure rate. Timepoint: Postoperaive days 45, 90, 135, 180, 225, 270. Method of measurement: Anteroposterio and lateral radiography views.
- Secondary Outcome Measures
Name Time Method Incidence of infection. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Bacterial culture.;Muscular trophism. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Physcial examination.;Incedence of mal-union. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Anteroposterio and lateral radiography views.;Pain severity. Timepoint: Postoperative days 45, 90, 135, 180, 225, 270. Method of measurement: Visual Analogue Scale (VAS).