Efficacy of platelet rich plasma in treatment of knee osteoarthritis:A single group pre & post intervention study
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/03/063715
- Lead Sponsor
- JLN Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Patients aged 45-65 years with either side OA knees (ASA class I and II) of either gender
History of pain in last month
Those with imaging findings (X-ray) of degenerative changes of the joint without significant deformity (diagnosed by KL classification ( Grade 2 and 3)
Patients with KL grading I ( doubtful disease) and grade 4 (Severe disease)
Patient with history of diabetes mellitus
On Immunosuppressive drugs
Collagen vascular disorders
Cancer or malignant disorders
Active infection/ wound of knee
Patients with autoimmune and platelet disorders
Treatment with anticoagulant and antiplatelet medications within 10 days before injection
Use of NSAIDs within 2 days before injection or unwilling to stop then post injection except paracetamol
History of knee articular injection of corticosteroid during previous 3 months or use of systemic corticosteroids 2 weeks before PRP injection
Patients with genu valgum/Varum greater than 20 degrees
Human immunocompromised virus, Hepatitis B virus, Hepatitis C virus, venereal Disease Research Laboratory virus positive cases
Knee surgery on affected side within last 12 months
Systemic or inflammatory knee disease
Presence of warm and tense joint effusion
High chances of loss of follow-up
History of trauma to affected knee
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pain will be assessed by WOMEC score and Visual Analogue ScoreTimepoint: Patients will be evaluated <br/ ><br>on 6 week, 3 months and 6 months after the first injection by a blinded observer <br/ ><br>for change in WOMAC score
- Secondary Outcome Measures
Name Time Method VAS scoreTimepoint: at baseline/ 6 week / 3 month and 6 months