Clinical Study of Effectiveness of Radiotherapy Before Surgery in High-risk Relapse Hepatocellular Cancer Patients

Not Applicable

• Conditions: Carcinoma, Hepatocellular
• Interventions: Radiation: radiotherapy

• Registration Number: NCT02580929
• Lead Sponsor: Peking Union Medical College

Brief Summary

This study aims to evaluate the effectiveness of radiotherapy before surgery in high-risk relapse hepatocellular cancer patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10
• Status Verified: 2015-10
• Study First Submitted: 2015-10-10
• Study First Submitted QC: 2015-10-18
• Study First Posted: 2015-10-20
• Last Update Submitted: 2015-10-21
• Last Update Posted: 2015-10-22
• Primary Completion: 2016-07
• Study Completion: 2017-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Clinical diagnosis of HCC
2. In high risk of recurrence of HCC but still can endure palliative resection
3. KPS scores are >90
4. With Child-Pugh Class A liver funcion, serum bilirubin< 1.5*normal maxism; ALT and AST< 1.5*normal maxism; normal creatinine and urea nitrogen; WBC>4×109/L, Hb>110g/L, PLT>90X109/L.
5. Have signed informed consent

Exclusion Criteria

1. HCC cannot be operated
2. With Child-Pugh Class B/C
3. Have other organ cancer, excluding curative non-melanotic skin cancer and carcinoma in situ of cervix
4. Have other severe disease
5. With active hepatitis
6. Have accepted local radiation therapy in other hospitals
7. KPS scores≤70
8. Tumor edges cannot be defined
9. Have severe cirrhosis complication
10. Intensity modulated radiation therapy cannot reach required dose
11. Cannot cooperate
12. Lactant or pregnant
13. Cannnot be informed

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
radiation	radiotherapy	-

Primary Outcome Measures

Name	Time	Method
mortality	5 years

Trial Locations

Locations (1)

WU FAN; 🇨🇳 Beijing, China