ACTRN12619001548123
Recruiting
Phase 3
Double NAC trial: Investigation of increased N-acetylcysteine dosing in patients treated for paracetamol overdose.
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- paracetamol overdose
- Sponsor
- Monash Health
- Enrollment
- 230
- Status
- Recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients requiring NAC following single acute or staggered overdose with abnormal liver function tests on presentation (ALT\>40 U/L), or paracetamol concentration more than double the nomogram treatment line, modified\-release paracetamol paracetamol ingestions.
Exclusion Criteria
- •Exclusion criteria will be patients who are pregnant, intoxicated or sedated patients with co\-ingested alcohol or sedating drugs. Single acute overdose patients who are at low risk \- normal ALT (\<40 IU/L) and paracetamol concentrations less than double the nomogram treatment line will be excluded. Patients with an ALT \>40 IU/L on admission and documented preexisting liver disease will be excluded.
Outcomes
Primary Outcomes
Not specified
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