Modulating Prefrontal Circuits Underlying Behavioral Flexibility in OCD: A TMS Study

Butler Hospital1 site in 1 country68 target enrollmentNovember 15, 2019

ConditionsObsessive-Compulsive Disorder

Overview

Phase: N/A
Intervention: Not specified
Conditions: Obsessive-Compulsive Disorder
Sponsor: Butler Hospital
Enrollment: 68
Locations: 1
Primary Endpoint: Resting-state functional connectivity with dorsal striatum
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study investigates whether slow-frequency repetitive transcranial magnetic stimulation targeting frontal pole can acutely modulate brain circuits which show abnormal functioning during behavioral flexibility in obsessive-compulsive disorder, as well as performance on a behavioral task.

Registry

clinicaltrials.gov

Start Date

November 15, 2019

End Date

December 2, 2022

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Butler Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•current primary diagnosis of obsessive-compulsive disorder and Yale-Brown Obsessive Compulsive Scale total score ≥ 16;
•18-55 years of age;
•ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent;
•either no use of psychiatric medication or stable psychiatric medication use for 6 weeks prior to study entry, limited to use of serotonin reuptake inhibitors and PRN use of benzodiazepines (other psychiatric medication use excluded), and
•right-handed.
•Inclusion Criteria: Healthy Control group
•18-55 years of age;
•ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent;
•right-handed.

Exclusion Criteria

•active problematic substance use;
•lifetime psychosis or bipolar mood disorder or OCD beliefs of delusional nature;
•clinically significant hoarding symptoms;
•active suicidal or homicidal ideation;
•significant neurological disease or intracranial pathology;
•use of medications which increase risk for seizures during TMS;
•significant or unstable medical disorders or contraindication to TMS or MRI scan.
•Exclusion Criteria: Healthy Control group
•current psychiatric diagnosis;
•lifetime psychosis, bipolar mood disorder, or OCD;