Meeting Protein Targets in Critically Ill Patients

Completed

• Conditions: Critical Illness; Dietary Modification

• Registration Number: NCT03319836
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

This is a retrospective study of protein and energy intake in enterally fed critically ill adult patients before and after the introduction of a very high protein enteral nutrition formula in a single center medical/surgical ICU.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-19
• Study Start: 2017-10-04
• Study First Submitted QC: 2017-10-19
• Study First Posted: 2017-10-24
• Primary Completion: 2018-02-16
• Study Completion: 2018-02-16
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-21
• Last Update Posted: 2018-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Adult patients ≥ 18 years of age, mechanically ventilated
• Received enteral nutrition for a minimum of five days during the first week of ICU admission

Exclusion Criteria

• Received parenteral nutrition during first week of ICU admission
• Acute renal failure not dialyzed
• Hepatic encephalopathy grade 3 or 4
• Intentional underfeeding/trophic feeding - including refeeding syndrome

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Daily total protein intake	Daily up to 7 days of ICU stay	Daily total protein intake and percent prescribed protein needs met during first week of ICU admission.

Secondary Outcome Measures

Name	Time	Method
Daily caloric intake - Total Calories	Daily up to 7 days of ICU stay	Total calories aggregate from all sources
Daily caloric intake from enteral nutrition	Daily up to 7 days of ICU stay	Daily caloric intake from enteral nutrition, and medications (i.e. Propofol)
Daily caloric intake - kcal/kg	Daily up to 7 days of ICU stay	Total volume consumed and weight will be used to measure kcal/kg
Percentage of prescribed calorie needs met	Daily up to 7 days of ICU stay	Percentage of prescribed calorie needs met
Feeding interruptions	Daily up to 7 days of ICU stay	Feeding interruptions; and reason for interruption, if recorded in electronic medical record/nursing flow sheets
Use of inotropes/vasopressors (highest daily dose prescribed)	Daily up to 7 days of ICU stay	Use of inotropes/vasopressors will be documented as a Yes/No.
Feeding tolerance	Daily up to 7 days of ICU stay	Feeding tolerance as recorded by clinicians in electronic medical record/nursing flow sheets \[gastrointestinal side effects observed and documented: vomiting, elevated Gastric Residual Volumes (\>200 mL), aspiration, pneumonia, diarrhea (Bristol stool chart definition and ≥ 3 liquid stools/day)\]

Trial Locations

Locations (1)

Hamilton Health Sciences; 🇨🇦 Hamilton, Ontario, Canada