Application of Guidelines for Medico-professional Supervision of Workers Exposed to Carcinogenic Action of Wood Dust: CERBois Cohort

Completed

• Conditions: Exposition to Wood Dust

• Registration Number: NCT02884232
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

The purpose is to evaluate feasibility of medical supervision of professionally active asymptomatic wood workers with questionnaires and nasofibroscopy.

Secondary purposes are:

* Feasibility evaluation of identification of former and actual professional expositions to wood dust and to various naso-sinusal carcinogenics in case of co-expositions (formaldehyde, chrome, nickel, leather)

* Description of abnormal symptoms identified by occupational doctor and needing an otorhinolaryngology test

* Description of results and examinations induced by nasofibroscopy in symptomatic or asymptomatic individuals: counting of naso-sinusal adenocarcinoma cases

* Evaluation of participation of workers retiring in 2 years after inclusion to medical supervision program

* Evaluation of information flow among different players

* Assessment of costs induced by this targeted screening: direct medical costs (screened pathologies, induced additional examinations...) and indirect costs for company (duration of worker absence for transfer, medical and additional examinations).

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Status Verified: 2016-08
• Study First Submitted: 2016-08-23
• Study First Submitted QC: 2016-08-25
• Last Update Submitted: 2016-08-25
• Study First Posted: 2016-08-30
• Last Update Posted: 2016-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Employee or craftsman
• Actual or former professional exposition to wood dust
• Onset of exposition to wood dust back to more than 30 years (latency >30 years)
• Cumulated exposition to wood dust longer than 12 months
• Exposition to wood dust during machining tasks (sawing, milling, planing, drilling, bridging) or all documented activities exposing to wood dust concentration > 1 mg/m3 for 8 hours
• Worker followed by occupational doctor of participant occupational health departments
• Worker accepting medico-professional supervision recommended by guidelines
• Affiliation to social security

Exclusion Criteria

• Difficulty with comprehension of wood auto-questionnaire

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Participation to medical supervision program of professionally active asymptomatic workers	27 months

Secondary Outcome Measures

Name	Time	Method
Evaluation of information flow among different players	27 months
Former and actual professional expositions to wood dust and to various naso-sinusal carcinogenics	Day 0
Presence of abnormal symptoms assessed by doctor, needing an otorhinolaryngology test	24 months
Counting of diagnoses of naso-sinusal adenocarcinoma in symptomatic and asymptomatic workers after nasofibroscopy	27 months
Participation to medical supervision program of workers retiring in 2 years after inclusion	Day 0
Medical costs Induced by screening	27 months

Trial Locations

Locations (6)

AHI 33; 🇫🇷 Bordeaux, France

Pôle Santé Travail; 🇫🇷 Lille, France

Gnmst-Btp; 🇫🇷 Paris, France

Ville de Paris; 🇫🇷 Paris, France

ACMS; 🇫🇷 Suresnes, France

Centres de Consultations de Pathologies Professionnelles; 🇫🇷 Vandoeuvre Les Nancy, France