Optimal Frequency of High-Intensity Interval Training for Centrally Obese Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 315
- 试验地点
- 1
- 主要终点
- Change in Body Fat
研究概览
简要总结
The aim of this study is to examine the therapeutic effectiveness of two different exercise frequencies of high-intensity interval training (HIIT; once versus thrice weekly, with matched weekly exercise volume) on improving cardiometabolic risk factors in centrally obese adults.
详细描述
HIIT is an emerging, popular, promising, cost-effective, and time-efficient exercise modality for managing obesity. Although lower-frequency HIIT is favorable for intervention adherence, the optimal exercise frequency of HIIT for alleviating obesity is unknown.
This study is a three-arm randomized controlled trial. Centrally obese adults will be randomly allocated to three groups: the usual care control, once and thrice-weekly HIIT groups. Led by research personnel, the usual care group will receive obesity-related health education. Led by athletic coaches, the HIIT intervention groups will receive 16 weeks of once or thrice weekly HIIT (with matched weekly exercise volume). Outcome measures of this study will be examined at baseline, 4 months (post-intervention), and 8 months (follow-up), by assessors blinded to group allocation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged above 18 years
- •Ethnic Chinese
- •Overweight (BMI ≥23 for Asian)
- •Centrally obese according to IDF and NCEP with Asian-specific cut-off (waist circumference ≥90 cm for males; ≥80 cm for females)
- •Males and females
排除标准
- •Medical and somatic conditions that prevent brisk walking
- •Chronic diseases affecting mobility and motor function (e.g., neurological disease, musculoskeletal disorder, spinal cord injury, autoimmune, arthritis, Parkinson's Disease)
- •Chronic diseases affecting cardiorespiratory and metabolic health (e.g., cancers, cardio-/cerebrovascular diseases, heart disease, diabetes mellitus, pneumonia, chronic pulmonary diseases, nephritis, nephrosis)
- •Signs of cardiac arrhythmia indicated by aberrant electrocardiography during incremental VO2max test
- •Regular moderate-to-vigorous intensity exercise (≥150 min weekly) in the past 3 months, as screened by a specially designed questionnaire
- •Daily smoking habit
- •Excess alcohol consumption (daily ≥30g for men, ≥20g for women) in the past six months
- •Claustrophobia
- •Surgery, therapy or medication for obesity or weight loss in the past six months (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, and dietitian-prescribed dietary program)
结局指标
主要结局
Change in Body Fat
时间窗: Baseline and 4 months
Total body fat mass will be assessed using dual-energy X-ray absorptiometry (DXA)
次要结局
- Change in Body Fat(Baseline and 8 months)
- Change in Abdominal Visceral Fat(Baseline and 4 and 8 months)
- Change in Fasting Low Density Lipoprotein Cholesterol (LDL-C)(Baseline and 4 and 8 months)
- Change in Fasting Total Cholesterol(Baseline and 4 and 8 months)
- Change in Proportion of Metabolic Syndrome Diagnosis(Baseline and 4 and 8 months)
- Change in Body Mass Index(Baseline and 4 and 8 months)
- Change in Diastolic Blood Pressure(Baseline and 4 and 8 months)
- Change in Fasting Glucose(Baseline and 4 and 8 months)
- Number of Adverse Events(Baseline and 4 and 8 months)
- Change in Abdominal Subcutaneous Fat(Baseline and 4 and 8 months)
- Change in Systolic Blood Pressure(Baseline and 4 and 8 months)
- Change in Fasting High Density Lipoprotein Cholesterol (HDL-C)(Baseline and 4 and 8 months)
- Change in PHQ-9 Score(Baseline and 4 and 8 months)
- Change in HADS-A Score(Baseline and 4 and 8 months)
- Change in Organ Fat(Baseline and 4 and 8 months)
- Change in Waist Circumference(Baseline and 4 and 8 months)
- Change in SF-12 Physical Component Summary Score(Baseline and 4 and 8 months)
- Change in SF-12 Mental Component Summary Score(Baseline and 4 and 8 months)
- Change in HADS-D Score(Baseline and 4 and 8 months)
- Change in GAD-7 Score(Baseline and 4 and 8 months)
- Change in Fasting Triglycerides(Baseline and 4 and 8 months)
研究者
Parco M. Siu, PhD
Associate Professor and Division Head
The University of Hong Kong