Impact of Acute Kidney Injury on Sarcopenia and Frailty in Patients With Liver Cirrhosis
- Conditions
- SarcopeniaFrailtyCirrhosisKidney Injury
- Registration Number
- NCT05389280
- Lead Sponsor
- Kangbuk Samsung Hospital
- Brief Summary
The aim of this prospective observational study is to evaluate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis.
- Detailed Description
The aim of this prospective study is to collect data on patients with liver cirrhosis and to investigate the impact of acute kidney injury on sarcopenia and frailty in patients with liver cirrhosis. If patients agree to participate in this clinical trial, the patients' data (such as age, sex, height, weight, nutrition status \[RFH-NPT\], history of medication, laboratory findings, endoscopic findings, and radiologic findings) will be collected in a research database. Renal injury was measured using conventional and novel serum biomarkers (serum creatinine, cystatin-C, neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, and interleukin-18. Sarcopenia was evaluated using skeletal muscle index on abdominal computed tomography. Frailty was measured using Liver Frailty Index. The research database will be updated to include data on patients' disease outcomes and follow-up care.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
- Liver cirrhosis
- aged over 20 years
- serum creatinine >1.5 mg/dL
- on dialysis
- liver transplant
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Number of Participants with Acute kidney injury up to 24 weeks an increase in SCr of 0.3 mg/dL (26.4 µmoL/L) in \<48 hours, or a 50% increase in SCr from a baseline within ≤3 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of