Musculoskeletal Health in Adult Haematoloigcal Cancer Survivors - a Mixed Methods Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 650
- 试验地点
- 1
- 主要终点
- Interivew study: To describe experience of adult lymphoma and leukaemia survivors on musculoskeletal health, musculoskeletal related care and musculoskeletal health information provision.
研究概览
简要总结
Haematological cancer treatment often includes use of high dose glucocorticoids (steroids), chemotherapy and radiotherapy and current evidence suggests that these patients may have lower bone mineral density after treatment when compared to the general population which can predispose them to increased risk of fragility fractures. Evidence of the impact of these musculoskeletal burden to patients (e.g. quality of life) are not available.
This study aims to describe musculoskeletal complications experienced by long-term haematological cancer survivors and examine the impact of the burden from the patient perspective. The study will be conducted in 2 parts; a questionnaire study and an interview study to help understand the extent of musculoskeletal problems experienced by this group of patients and the impact of this on quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 or above at diagnosis of haematological cancer
- •Diagnosis of haematological cancers: lymphoma or leukaemia
- •Cancer survivors as recorded in the local database of lymphoma and haematopoietic stem cell transplant database
- •Able to give written informed consent
- •Able to read and understand English
排除标准
- •1.Currently receiving any active cancer treatment
- •Interview study
- •Inclusion Criteria:
- •Age 18 or above at diagnosis of haematological cancer
- •Diagnosis of haematological cancers: lymphoma or leukaemia
- •Cancer survivors as recorded in the local database of lymphoma and haematopoietic stem cell transplant database
- •Able to give written or verbal informed consent
- •Able to read and understand English
- •Exclusion Criteria:
- •1 .Currently receiving any active cancer treatment
结局指标
主要结局
Interivew study: To describe experience of adult lymphoma and leukaemia survivors on musculoskeletal health, musculoskeletal related care and musculoskeletal health information provision.
时间窗: overall length of the study - 6 months
Semi-structured qualitative interviews will be conducted with a topic guide to ensure same broad topics are explored in the interviews on musculoskeletal health experience, care and information provision.
Questionniare study: To measure prevalence of sarcopenia and frailty among adult lymphoma and leukaemia survivors
时间窗: overall length of the study - 6 months
Validated questionniares will be used to assess if patients have sarcopenia (SARC-F questionnaire) and frailty (FiND questionnaire).
Questionniare study: To calculate the 10-year probability of hip fracture and major osteoporotic fracture (clinical spine, forearm, hip or shoulder fracture) of adult lymphoma and leukaemia survivors
时间窗: overall length of the study - 6 months
The 10-year probability of hip fracture and major osteoporotic fracture (clinical spine, forearm, hip or shoulder fracture) of adult lymphoma and leukaemia survivors will be calculated using the Fracture Risk Assessment Tool (FRAX) and Q-Fracture calculator.
Questionniare study: To measure prevalence of musculoskeletal conditions and related symptoms experienced by adult lymphoma and leukaemia survivors
时间窗: overall length of the study - 6 months
Musculoskeletal conditions and related symptoms will be recorded by patients on the study specific questionnaire and the validated questionnaire Nordic musculoskeletal questionnaire (NMQ-E) and gait, arms, legs and spine (GALS) assessment
Questionniare study: To assess quality of life and musculoskeletal function related quality of life of adult lymphoma and leukaemia survivors
时间窗: overall length of the study - 6 months
This will be assessed using validated questionnaires - Short Form Survey (SF36) and Short Musculoskeletal Function Assessment (SMFA).
次要结局
- Questionnaire study: To describe the likely risk factors that may be associated with musculoskeletal consequences of adult lymphoma and leukaemia survivors Impact of musculoskeletal health(overall length of the study - 6 months)