Can perioperative vitamin C supplementation reduce the risk of arthrofibrosis after total knee arthroplasty?

Completed

• Conditions: Arthrofibrosis; Musculoskeletal Diseases

• Registration Number: ISRCTN40250576
• Lead Sponsor: Cantonal Hospital St Gallen

Brief Summary

2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29955932

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2016-07-12
• Study Start: 2018-02-08
• Last Update Posted: 30 July 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

1. Patients with primary osteoarthritis of knee joint undergoing TKA presenting with grade 3 or 4 osteoarthritis (Kellgren-Lawrence score)
2. Age =18 years
3. Written informed consent, including written consent to participate in the local prosthesis registry of the hospital

Exclusion Criteria

1. History of nephrolitiasis, hematochromatosis, uremia, beta-thalassemia
2. Known intolerance to vitamin C or any of the excipients
3. Dietary vitamin C intake <3 days before intervention
4. CRP values >10mg/l

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knee joint ROM measured with a goniometer by a trained study nurse who was blinded to the research history, assessed preoperatively, at 8 weeks and 12 months postoperatively

Secondary Outcome Measures

Name	Time	Method
1. Incidence of arthrofibrosis (AF), defined as extension deficit >5° and/or = 100° flexion of the knee, measured at 8 weeks and 12 months postoperatively<br>2. Vitamin C plasma concentrations measured in µmol/l before surgery and 4 and 7 days after surgery<br>3. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) measured at 8 weeks and 12 months postoperatively<br>4. The Forgotten Joint Score-12 (FJS-12) measured at 8 weeks and 12 months postoperatively