The Use of Injectable Plasma Versus the Use of Simvastatin Gel in Surgical Management of Bony Defect in Dentistry
- Conditions
- Intra-bony Pockets
- Interventions
- Other: injectable plasma rich fibrin
- Registration Number
- NCT04824898
- Lead Sponsor
- Ain Shams University
- Brief Summary
Simvastatin (SMV) is one of the family members of statins, it has been showed in many previous studies that the simvastatin when dissolved with methylcellulose in situ gel with a concentration of 1.2% (SMV) approximately, can have a significant decrease in the pocket depth, regain the clinical attachment loss (CAL), and improve the bone level.
and the platelets concentrate has been introduced which is the injectable plasma rich fibrin (I-PRF), as it contains platelets and leukocytes, stem cells and endothelial cells that why it is called "blood concentrate ". So, it is proposed as treatment option in different periodontal procedures such as treatment of intra-bony defects,
- Detailed Description
Group I ( Experimental group): will include 12 patients undergoing open flap debridement (OFD) followed by single application of I-PRF. Oral Hygiene measure will be instructed following treatment and maintenance visits will be given to them.
Group II (Control group): will include 12 patients undergoing open flap debridement (OFD) followed by application of 1.2% simvastatin gel. Oral Hygiene measure will be instructed following treatment and maintenance visits will be given to them.
* Oral hygiene instructions will be given to all patients.
* Full mouth Scaling and root planing (SRP) will be performed under local anesthesia.
* 4 to 8 weeks after the non-surgical periodontal therapy patients will be reassessed clinically and radiographically For all patients who are suitable for the study the following clinical and radiographic evaluation parameters will be measured: (All parameters will be recorded Pre-operatively (base line) and 6 months Post operatively by an examiner who will be masked to the type of treatment received by the individuals).
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 24
-
• Age range between 25 and 40 years
- Patients with severe chronic periodontitis having probing depth (PD) ≥6 mm and clinical attachment loss (CAL) ≥5 mm , or Stage III periodontitis
- Patient having vertical bone loss ≥3 mm (distance between alveolar crest and base of the defect as confirmed by preoperative intraoral periapical radiographs using standardized parallel technique.)
- Good compliance with the plaque control instructions following initial therapy
- Availability for follow up and maintenance program.
-
• Patient with any systemic disease or conditions
- Patient using antibiotic, anti-inflammatory, and immunosuppressive therapy during the preceding 3 months before the start of trial and during the study.
- Patients who have undergone any periodontal treatment in the last 6 months
- Pregnant and Lactating.
- Reported allergy to any type of statins
- Subjects who were tobacco or alcohol users
- Vulnerable group of patients (e.g.: prisoners , handicapped , or decisionally impaired individuals )
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description I-prf injectable plasma rich fibrin Injectable plasma rich fibrin will be collected from each patient in group II and the applied after open flap debridment simvastatin 1.2%gel Simvastatin simvastatin 1.2%gel applied after open flap debridment in group I
- Primary Outcome Measures
Name Time Method Gingival index (GI) change from basline at 6 months clinical score
Plaque index (PI) change from basline at 6 months clinical score
Probing depth (PD) change from basline at 6 months clinical score
Clinical attachment level (CAL) change from basline at 6 months clinical score
- Secondary Outcome Measures
Name Time Method radiographIc from baseline at 6 months assess the alveolar bone level radiographically
Trial Locations
- Locations (1)
Ain Shams University
🇪🇬Cairo, New Cairo, Egypt