Effect of pre-operative Simvastatin use on fibrinolytic activity during surgery.
Recruiting
- Conditions
- hysterectomy with or without a unilateral or bilateral salpingooophorectomy per laparotomy for benigne pathology.
- Registration Number
- NL-OMON25154
- Lead Sponsor
- BWJ HellebrekersHaga Teaching Hospital, Department of GynecologyLeyweg 2752545 CH The Hague0702100000
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. 18 years or older;
2. Scheduled for hysterectomy with or without a unilateral or bilateral salpingooophorectomy per laparotomy for benigne pathology;
Exclusion Criteria
1. Non compliance with one or several inclusion criteria;
2. Pregnant women;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Change in CRP plasma level from study entry to surgery;<br /><br>2. Peak plasma level of CRP after surgery;<br /><br>3. Area under curve of postoperative CRP levels in plasma;<br /><br>4. tPA concentration in plasma at surgery;<br /><br>5. tPA activity in plasma at surgery;<br /><br>6. tPA concentration in peritoneal fluid at surgery;<br /><br>7. tPA activity in peritoneal fluid at surgery.
- Secondary Outcome Measures
Name Time Method 1. Peak level in plasma of distribution FM/FbDP's;<br /><br>2. Area under curve of postoperative distribution FM/FbDP's in plasma.