Comparison of adaptive ventilation mode with low tidal volume mode in patients with acute respiratory distress syndrome (ARDS)- a pilot randomized cross-over study
Not Applicable
- Conditions
- Acute respiratory distress syndrome (ARDS)Respiratory - Other respiratory disorders / diseases
- Registration Number
- ACTRN12622000117718
- Lead Sponsor
- Flinders Medical Centre IC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
who were greater than equal to 18 years of age, intubated, and within 48h of a diagnosis of moderate/severe ARDS (PaO2/FiO2 less than or equal to 200 mmHg, PEEP more than or equal to 5 cm H2O, bilateral opacities on chest X-ray and respiratory failure not fully explained by cardiac failure or fluid overload)
Exclusion Criteria
patients with active bronchospasm or a history of significant chronic obstructive pulmonary disease or asthma, lack of consent (treating physician or next of kin), inevitable and imminent death, pregnancy, those receiving ECMO, or involvement in other prospective clinical studies.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Driving pressure as measured by ventilator readings[6 hours post-commencement of each cycle of either LTV or AVM2 ventilation]
- Secondary Outcome Measures
Name Time Method