Evaluation of Lung Deposition of Aerosol Via HFNC in Healthy Adults

Not Applicable

• Conditions: Healthy
• Interventions: Other: 10l/min; Other: 30l/min; Other: 50l/min

• Registration Number: NCT02519465
• Lead Sponsor: Universidade Federal de Pernambuco

Brief Summary

The aerosol associated with noninvasive ventilation (NIV) and high flow therapy with nasal interface have been employed in an attempt to relieve respiratory distress and optimize the deposition of drugs by inhalation.

Some studies report the effects of NIV association with fogging in healthy subjects, asthmatics and COPD 7.8, but studies evaluating the association between high flow nasal mist interface and therapy are scarce and most are found in vitro and animal models. The objective of this study is to evaluate the deposition of the aerosol scintigraphy using the high flow nasal interface system with vibrating mesh nebulizers using in healthy adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07
• Status Verified: 2015-08
• Primary Completion: 2015-08
• Study Completion: 2015-08
• Study First Submitted: 2015-08-06
• Study First Submitted QC: 2015-08-10
• Last Update Submitted: 2015-08-10
• Study First Posted: 2015-08-11
• Last Update Posted: 2015-08-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• The study included healthy individuals of both sexes,
• between 18 to 65 years,
• without history of lung disease and forced vital capacity (FVC) or forced expiratory volume in the first second (FEV1) higher or equal to 80% from predicted values,
• ability to verbal commands understand and
• willing to provide signed consent to participate in this study.

Exclusion Criteria

• Participants were excluded if there unable to understand and follow the procedures and were pregnant and unable to tolerate nebulization.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
COLD FLOW	30l/min	The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen cold
COLD FLOW	10l/min	The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen cold
HEATED FLOW	10l/min	The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen heated .
HEATED FLOW	30l/min	The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen heated .
HEATED FLOW	50l/min	The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen heated .
COLD FLOW	50l/min	The volunteers were randomly allocated into three groups - group 1 - 10l/min cold or heated, group 2 - 30l/min cold or heated, group 3 - 50 l /min - cold or heatedPhase 1 - 10l/min or 30l/min or 50l/min of the oxygen cold

Primary Outcome Measures

Name	Time	Method
radioaerosol deposition index into the lungs	1 month

Trial Locations

Locations (1)

Laboratório de Fisiologia e Fisioterapia Cardiopulmonar; 🇧🇷 Recife, Pernambuco, Brazil