NCT06452459尚未招募不适用
Evaluation of Glymphatic Function With MRI
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 主要终点
- Contrast enhancement
研究概览
简要总结
This study aims at identifying neuroimaging markers of glymphatic function in humans.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ability to undergo MRI without anesthesia
- •Calculated GFR greater or equal to 60 mL/min/1.73 m2
排除标准
- •Inability to obtain consent
- •Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant
- •Known allergic or hypersensitivity reactions to gadolinium
- •Three or more drug allergies from separate drug classes
- •Recent or expected beed for imaging with iodinated contrast
- •Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe
- •History of neurosurgical procedure or cervical surgery
- •Current use of anticoagulation medications
- •Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)
结局指标
主要结局
Contrast enhancement
时间窗: 2 weeks
Measurement of contrast intensity in brain parenchyma
次要结局
未报告次要终点
研究者
Juan Piantino
Associate Professor
Oregon Health and Science University
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