Quantitation of Glymphatic Functioning in Sleep and Meditative States

Vanderbilt University Medical Center1 site in 1 country75 target enrollmentFebruary 1, 2021

ConditionsParkinson Disease Sleep

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Parkinson Disease
Sponsor: Vanderbilt University Medical Center
Enrollment: 75
Locations: 1
Primary Endpoint: CSF flow change
Status: Completed
Last Updated: 8 months ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.

Detailed Description

This study is evaluating the glymphatic system during awake, sleep, and meditative states.

Registry

clinicaltrials.gov

Start Date

February 1, 2021

End Date

December 1, 2024

Last Updated

8 months ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Vanderbilt University Medical Center

Responsible Party

Principal Investigator

Daniel Claassen

Associate Professor

Vanderbilt University Medical Center

Eligibility Criteria

Inclusion Criteria

•Ages 14-45
•"Adept meditator status"

Exclusion Criteria

•Any non-MR compatible material implant, or contraindication to MR scanning
•Claustrophobia or inability to lie still for prolonged periods of time
•Participants with a recent (less than 2 months) infection, tattoo, or wound
•No consumption of stimulants or alcohol within 12 hours of the study visit
•clinical diagnosis of any major neurological or psychological condition
•Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors