Quantitation of Glymphatic Functioning in Sleep and Meditative States

Not Applicable

Recruiting

• Conditions: Parkinson Disease; Sleep
• Interventions: Behavioral: Meditation

• Registration Number: NCT04506892
• Lead Sponsor: Vanderbilt University Medical Center

Brief Summary

This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.

Detailed Description

This study is evaluating the glymphatic system during awake, sleep, and meditative states.

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study First Submitted: 2020-07-17
• Study First Submitted QC: 2020-08-06
• Study First Posted: 2020-08-10
• Study Start: 2021-02-01
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-29
• Last Update Posted: 2024-04-30
• Primary Completion: 2026-07
• Study Completion: 2027-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Ages 14-45
• "Adept meditator status"

Read More

Exclusion Criteria

• Any non-MR compatible material implant, or contraindication to MR scanning
• Claustrophobia or inability to lie still for prolonged periods of time
• Participants with a recent (less than 2 months) infection, tattoo, or wound
• No consumption of stimulants or alcohol within 12 hours of the study visit
• clinical diagnosis of any major neurological or psychological condition
• Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Adept Meditators	Meditation	Subjects will undergo scanning during awake, sleep deprived, and meditative states of consciousness.

Primary Outcome Measures

Name	Time	Method
CSF flow change	baseline to 24 hours	Using MRI to assess the change in CSF flow in awake, sleep deprived, and meditative states

Secondary Outcome Measures

Name	Time	Method
EEG changes	baseline to 24 hours	Looking at brain wave changes before and after intervention in Alpha, Beta, and Delta waves associated with light to deep sleep. The lowest bandwidth for alpha waves is 8 while the highest is 12. The lowest bandwidth for Beta waves is 13 Hz while the highest is 30 Hz. The lowest bandwidth for Delta waves is .4 Hz and the highest is 4 Hz.

Trial Locations

Locations (1)

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States