Glymphatic MRI Study

Not yet recruiting

• Conditions: Sleep Deprivation

• Registration Number: NCT06452459
• Lead Sponsor: Oregon Health and Science University

Brief Summary

This study aims at identifying neuroimaging markers of glymphatic function in humans.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-06
• Study First Submitted: 2024-06-05
• Study First Submitted QC: 2024-06-05
• Last Update Submitted: 2024-06-05
• Study First Posted: 2024-06-11
• Last Update Posted: 2024-06-11
• Study Start: 2024-07-01
• Primary Completion: 2027-07-01
• Study Completion: 2028-07-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Ability to undergo MRI without anesthesia
• Calculated GFR greater or equal to 60 mL/min/1.73 m2

Exclusion Criteria

• Inability to obtain consent
• Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant
• Known allergic or hypersensitivity reactions to gadolinium
• Three or more drug allergies from separate drug classes
• Recent or expected beed for imaging with iodinated contrast
• Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe
• History of neurosurgical procedure or cervical surgery
• Current use of anticoagulation medications
• Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Contrast enhancement	2 weeks	Measurement of contrast intensity in brain parenchyma