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临床试验/NCT06452459
NCT06452459
尚未招募
不适用

Evaluation of Glymphatic Function With MRI

Oregon Health and Science University0 个研究点目标入组 10 人2024年7月1日

概览

阶段
不适用
干预措施
未指定
疾病 / 适应症
Sleep Deprivation
发起方
Oregon Health and Science University
入组人数
10
主要终点
Contrast enhancement
状态
尚未招募
最后更新
去年

概览

简要总结

This study aims at identifying neuroimaging markers of glymphatic function in humans.

注册库
clinicaltrials.gov
开始日期
2024年7月1日
结束日期
2028年7月1日
最后更新
去年
研究类型
Observational
性别
All

研究者

责任方
Principal Investigator
主要研究者

Juan Piantino

Associate Professor

Oregon Health and Science University

入排标准

入选标准

  • Ability to undergo MRI without anesthesia
  • Calculated GFR greater or equal to 60 mL/min/1.73 m2

排除标准

  • Inability to obtain consent
  • Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant
  • Known allergic or hypersensitivity reactions to gadolinium
  • Three or more drug allergies from separate drug classes
  • Recent or expected beed for imaging with iodinated contrast
  • Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe
  • History of neurosurgical procedure or cervical surgery
  • Current use of anticoagulation medications
  • Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)

结局指标

主要结局

Contrast enhancement

时间窗: 2 weeks

Measurement of contrast intensity in brain parenchyma

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