Skip to main content
MedPathMedPath Home
Clinical Trials/NCT06452459
NCT06452459
Not yet recruiting
Not Applicable

Evaluation of Glymphatic Function With MRI

Oregon Health and Science University0 sites10 target enrollmentJuly 1, 2024
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsSleep Deprivation

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Sleep Deprivation
Sponsor
Oregon Health and Science University
Enrollment
10
Primary Endpoint
Contrast enhancement
Status
Not yet recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

This study aims at identifying neuroimaging markers of glymphatic function in humans.

Registry
clinicaltrials.gov
Start Date
July 1, 2024
End Date
July 1, 2028
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Juan Piantino

Associate Professor

Oregon Health and Science University

Eligibility Criteria

Inclusion Criteria

  • •Ability to undergo MRI without anesthesia
  • •Calculated GFR greater or equal to 60 mL/min/1.73 m2

Exclusion Criteria

  • •Inability to obtain consent
  • •Subject is incarcerated, pregnant, or lactating or suspects they may be pregnant
  • •Known allergic or hypersensitivity reactions to gadolinium
  • •Three or more drug allergies from separate drug classes
  • •Recent or expected beed for imaging with iodinated contrast
  • •Contraindications to MRI: claustrophobia, weight greater than maximum MRI scanner capacity, presence of metallic foreign body, or implanted devices not documented as MRI safe
  • •History of neurosurgical procedure or cervical surgery
  • •Current use of anticoagulation medications
  • •Contraindication to lumbar puncture (creatinine or INR elevated above laboratory standard cutoffs)

Outcomes

Primary Outcomes

Contrast enhancement

Time Frame: 2 weeks

Measurement of contrast intensity in brain parenchyma

Similar Trials

Completed
Not Applicable
Quantitation of Glymphatic Functioning in Sleep and Meditative StatesParkinson DiseaseSleep
NCT04506892Vanderbilt University Medical Center75
Active, not recruiting
Early Phase 1
Quantitative Imaging of Brain Glymphatic Function in HumansParkinson Disease
NCT04768101Vanderbilt University Medical Center140
Completed
Not Applicable
Glymphatic Kinetics In Healthy Adult VolunteersHealthy
NCT03218111Weill Medical College of Cornell University19
Completed
Early Phase 1
Quantitative MR Methods for Lipid EmulsionsHealthy
NCT02226029University of Zurich22
Recruiting
Not Applicable
Study of the Glymphatic System in MigraineMigraine
NCT05907655IRCCS San Raffaele50