Physical activity and cognition in early-onset dementia.

Completed

Conditions: early-onset dementia
presenile dementia
10012272

Registration Number: NL-OMON37056

Lead Sponsor: Vrije Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 262

Inclusion Criteria

Main study:
- Diagnosis of early-onset dementia (onset of complaints < 66 years) (among others Alzheimer's disease, Vascular dementia, Frontotemporal dementia).
- Relatively early stage of dementia (MMSE * 16)
- Primary caregiver available;Extension:
- Diagnosis of (pre)senile dementia, or presence of similar symptoms due to a different
condition.
- Participant has to be able to walk, or when the participant is bound to a wheelchair he has to be physically active.
- Gradual progression of cognitive disorders

Exclusion Criteria

Main study:
- Bound to a wheelchair
- Neurodegenerative diseases at which motor symptoms are the primary problems, such as M. Parkinson and M. Huntington.
- Cardiovascular problems, such as severe cardiac problems or severe hypertension.
- Abuse of alcohol or other substances
- Trauma capitis in the medical history, at which a loss of consiousness was present of more than 15 minutes
- Extended history of psychiatry (major depression , bipolar disroder, psychosis)
- Severe visual problems
- Severe auditive problems
- Insufficient mastery of the Dutch language;Extension: same exclusion criteria

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters in the cross-sectional study will be measures<br /><br>concerning physical functioning (question 1a) and measures concerning global<br /><br>cognitive functioning, mental speed, and executive functioning (question 1b).<br /><br>Primary study parameters in the intervention study will be measures concering<br /><br>global cognitive functioning, mental speed, instrumental activities of daily<br /><br>living, and quality of live. </p><br>

Secondary Outcome Measures