A Study Comparing The Efficacy and Safety of Jessner's Solution And Salicylic Acid 30% Chemical Peel and in the Management of Acne Vulgaris and Post Acne Hyperpigmentatio

Phase 4

Completed

• Conditions: Acne VulgarisPost Acne Hyperpigmentation; Acne Vulgaris; Post Acne Hyperpigmentation

• Registration Number: TCTR20190118001
• Lead Sponsor: Dermatological Society of Malaysia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-12-15
• Study Start: 2019-01-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

1.Males and females with acne vulgaris aged ≥ 18 years old
2.Should have at least 10 inflammatory AND/ OR non-inflammatory lesions at each side of the face
3.Have acne for more than 6 months

Exclusion Criteria

1.Other forms of acne (acne conglobata, acne excoriate, acne rosacea, acne cosmetica, pomade acne, acne fulminans, acne keloidalis nuchae, acne chloracne, acne mechanica and acne medicamentosa)
2.Nodulocystic acne
3.On oral antibiotic for the last 1 months
4.On oral isotretinoin for the last 6 months
5.On topical antimicrobial or tretinoin for the last 2 weeks
6.Photosensitivity
7.Recent (2-6months) facial undermining surgery (blepharoplasty, rhytidectomy, brow lift, liposuction) in the treatment area
8.If there is any active or past infection, such as HSV, herpes zoster infection
9.If there is any active bacterial folliculitis at this moment
10.History of keloid
11.Poor skin turgor
12.If patient is currently pregnant or lactating
13.Other comorbidities, especially immunocompromising diseases (possibility of dealy healing, increased susceptibility to infection, or excessive pigmentation after peeling)
14.If there is any known allergy to the active ingredients in the preparation
15.Patients who have any other dermatoses, especially facial dermatoses
16.Patients who like outdoor activities and couldn’t comply to sunprotection.
17.Fitzpatrick skin type I-II
18.Patients who had a difference of 2 grades or above, comparing one side of the face to another.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in total number of inflammatory lesions and non-inflammatory lesions. At each clinic visit lesions count

Secondary Outcome Measures

Name	Time	Method
Changes in the Michaelson Acne Score (MAS) At each clinic visit Michaelsson Acne Score,Changes in post acne hyperpigmentation index (PAHPI) at each clinic visit PAHPI,The patient’s satisfactory rate towards the treatment Last clinic visit Visual Analogue Scale,The frequency of overall all adverse reaction towards the treatment At each clinic visit Frequency