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Clinical Trials/NCT05466006
NCT05466006
Recruiting
Not Applicable

Peri-implant Soft Tissue Volume Changes After Treatment of Small Buccal Dehiscence With Volume-stable Collagen Matrix or Connective Tissue Graft: a Randomized Controlled Clinical Trial

University of Turin, Italy1 site in 1 country28 target enrollmentSeptember 5, 2022
ConditionsDental Implants

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Dental Implants
Sponsor
University of Turin, Italy
Enrollment
28
Locations
1
Primary Endpoint
Pain (VAS scale)(0-10 with higher values indicating worse outcomes)
Status
Recruiting
Last Updated
2 years ago

Overview

Brief Summary

This study was designed to assess peri-implant soft tissue health, volume and marginal stability at implants sites which presented small buccal bone dehiscences (<3mm evaluated in a vertical direction) at the time of insertion. Patients will be then randomly allocated to receive grafting with connective tissue graft or volume stable collagen matrix and evaluated at 3 months after surgery and at 12 months of follow up after crown placement.

Registry
clinicaltrials.gov
Start Date
September 5, 2022
End Date
June 30, 2024
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
University of Turin, Italy
Responsible Party
Principal Investigator
Principal Investigator

Mario Aimetti

Professor

University of Turin, Italy

Eligibility Criteria

Inclusion Criteria

  • Single tooth edentulous space
  • Expected small buccal bone dehiscence (≤3mm evaluated in a vertical direction) assessed according to the prosthetically guided position of an implant of 4 mm in diameter planned using the pre-surgical CBCT
  • Completed non-surgical periodontal therapy (if needed)
  • FMPS and FMBS \< 20%

Exclusion Criteria

  • Age \< 18 years old
  • Pregnancy or lactation
  • Heavy smokers (\> 10 cigarette/day)
  • Conditions or diseases contraindicating surgical interventions
  • Absence of the expected small buccal bone dehiscence (≤3mm evaluated in a vertical direction) verified after implant placement
  • Need for bone regeneration at the implant site

Outcomes

Primary Outcomes

Pain (VAS scale)(0-10 with higher values indicating worse outcomes)

Time Frame: 12 months

Subjective pain experienced by the patient expressed in a VAS scale

Volumetric buccal soft tissue changes (-5 to +5 mm with positive values representing an increase in volume)

Time Frame: 12 months

Mean linear change in mm at the buccal aspect 1mm below the soft tissue margin

Mucosal recession at the buccal aspect of the implant site (0-15 mm with higher values indicating worse outcomes)

Time Frame: 12 months

The distance between the crown margin and the mucosal margin

Bleeding on probing (0 no bleeding, 1 presence of bleeding)

Time Frame: 12 months

Bleeding after probing within 15 seconds

Change in Buccal Probing Pocket Depth (PD) at implant site (0-15 mm with higher values representing worse outcomes)

Time Frame: 12 months

The distance between the buccal soft tissue margin and the base of the pocket

Study Sites (1)

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