Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock

Recruiting

• Conditions: Acute Coronary Syndrome; Cardiogenic Shock

• Registration Number: NCT05426083
• Lead Sponsor: University of Minnesota

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-6-15
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Age 18-75 years<br><br> - SCAI D/E CS requiring VA-ECMO support based on treating team's judgement.<br><br> - MAP >65 mmHg on <3 vasopressors/inotropes at the time of consent<br><br> - Cardiogenic shock due to acute coronary syndrome identified by coronary angiography<br> at the index hospitalization per standard cardiology practice<br><br>Exclusion Criteria:<br><br> - VA-ECMO for sepsis, pulmonary embolism, COVID-19 related cardiorespiratory failure,<br> severe RV failure due to severe idiopathic pulmonary hypertension<br><br> - CS due to other (non-ACS) etiologies<br><br> - Known patient with severe left ventricular dysfunction and stage IV NYHA heart<br> failure being evaluated for or with a history of LVAD and transplantation prior to<br> commencement of VA-ECMO<br><br> - Profound vasoplegia with MAP <65 mmHg on 3 vasopressors/inotropes<br><br> - Moderate to severe aortic regurgitation (contraindication to VA-ECMO)<br><br> - Moderate to severe aortic stenosis (contraindication to LV instrumentation with PV<br> loop catheter)<br><br> - Bleeding complications requiring ongoing transfusions of blood products<br><br> - Ischemic lower extremities<br><br> - Evidence of circuit thrombosis or fibrin accumulation (turndown increases risk for<br> stroke and clot formation)<br><br> - Evidence of sepsis or septic shock<br><br> - Evidence of LV thrombus on echocardiography (contraindication for accessing LV<br> cavity with catheters)

Exclusion Criteria

Not provided

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pressure-volume loops at the highest level of VA-ECMO support and the lowest level of VA-ECMO support.