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临床试验/NCT07726498
NCT07726498尚未招募不适用

STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging

University of Leicester1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2026年8月1日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
200
试验地点
1
主要终点
Isometric plantarflexor strength testing

研究概览

简要总结

The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily activities. By assessing calf strength, it is possible to identify people at risk of falls, and a condition called sarcopenia (which means loss of muscle mass, strength and function). Unfortunately, most of the studies that have examined this have used specialist equipment unavailable to hospital staff. Our study aims to use commercially available equipment to explore the relationship between plantarflexor muscle strength and physical performance in adults living with or without sarcopenia, including those at risk of it. The study will determine if stronger/weaker calf muscles associated with sarcopenia influence the ability to walk and do things more easily. We will complete strength tests of the calf, thigh and hand, assess walking using a special camera system, use an ultrasound scan to look at the Achilles tendon, use a scan to look at how stiff your calf muscles are, assess your body composition, complete a physical performance test and some questionnaires. Each participant will complete the measures during one clinic visit

详细描述

This study aims to assess the relationship between plantarflexor (calf muscles) muscle strength and physical performance between people with and without sarcopenia. The measurements include Isometric plantarflexor strength testing, Theia markerless motion capture system, Ultrasound Tissue Characterization Imaging, Elastography, Grip strength, Isometric Knee Extension Strength Test, Bioelectrical Impedance analysis, Short Physical Performance Battery. In addition the SARC-F, Falls Efficacy Scale- International (FES-I), EuroQol- 5 Dimension (EQ-5D-5L) and Short-Form-12-health-survey (SF-12) questionnaires will be completed.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Participant is able and willing to provide informed consent to participate in the study
  • Aged 18 years or over
  • Ambulatory status: able to walk independently with or without aids
  • Able to attend clinic

排除标准

  • Participant is unwilling or unable to give informed consent.
  • Palliative/ end of life
  • Moderate to severe communication difficulties/ cognitive function
  • Lower limb surgery within the last 6 months
  • Recent lower limb fracture
  • Unstable cardiopulmonary conditions
  • Severe impairments of vision or vestibular system
  • Lower limb corticosteroid injection within the last 6 months
  • No restriction on language

结局指标

主要结局

Isometric plantarflexor strength testing

时间窗: Baseline

Isometric plantarflexor strength will be tested using the Fysiometer C-station

次要结局

  • Theia markerless motion capture system(Baseline)
  • Ultrasound Tissue Characterization Imaging(Baseline)
  • Elastography(Baseline)
  • Grip strength(Baseline)
  • Isometric Knee Extension Strength Test(Baseline)
  • Bioelectrical Impedance analysis(Baseline)
  • Short Physical Performance Battery(Baseline)
  • SARC-F questionnaire(Baseline)
  • Falls Efficacy Scale- International (FES-I)(Baseline)
  • EuroQol- 5 Dimension (EQ-5D-5L)(Baseline)
  • Short-Form-12-health-survey (SF-12)(Baseline)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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