CTRI/2021/03/032323尚未招募未知
Clinical, Epidemiological and Hematological profile of Hemophagocytic Lymphohistiocytosis in Children less than 12 years and Rate of decline of Ferritin as a prognostic marker for disease outcome.
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
- one
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Children less than 12yrs fulfilling criteria of Hemophagocytic lymphohistiocytosis.
- •1.A molecular diagnosis consistent with HLH (e.g., PRF mutations, SAP mutations) or
- •2. Presence of 5 of the following 8 symptoms, signs, or laboratory abnormalities:
- •b. Splenomegaly
- •c. Cytopenia (affecting >=2 cell lineages; hemoglobin <=9 g/dL [or <=10 g/dL for infants <4 wk old], platelets <100,000/μL, neutrophils <1,000/μL)
- •d. Hypertriglyceridemia (>=265 mg/dL) and/or hypofibrinogenemia (<=150 mg/dL)
- •e. Hemophagocytosis in the bone marrow, spleen, or lymph nodes without evidence of malignancy
- •f. Low or absent natural killer cell cytotoxicity
- •g. Hyperferritinemia (>=500 ng/mL)
- •h. Elevated soluble CD25 (interleukin-2Rα chain; >=2,400 U/mL)
排除标准
- •Macrophage Activation Syndrome (MAS) associated with Autoimmune disease
- •1.Systemic-onset juvenile idiopathic arthritis 2.Systemic lupus erythematosus
- •3.Enthesitis-related arthritis
- •4.Inflammatory bowel disease
研究者
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