Clinical Profile and Cognitive Status in Chronic Obstructive Pulmonary Disease's Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Cognitive impairment
研究概览
简要总结
Chronic obstructive pulmonary disease (COPD) is a chronic condition involving an impairment in functionality and in the execution of activities of daily life. The hypothesis of this study is to examine the relationship between cognitive status and clinical profile (respiratory, sleep quality, nutritional status) in patients with chronic obstructive pulmonary disease in two different moments: exacerbation or stable situation.
详细描述
Chronic obstructive pulmonary disease is a pathology with a systemic impact with a progressive evolution that is characterized by the presence of chronic airflow obstruction.
Patients with COPD may have problems with cognitive functioning, either globally or in single cognitive domains, such as information processing, attention and concentration, memory, executive functioning and self-regulation.
Several studies have determined the prevalence of cognitive impairment in COPD compared to healthy control subjects, reaching very high levels, 36% of COPD patients with mild cognitive impairment compared with 12 % non- COPD subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of chronic obstructive pulmonary disease with exacerbation or stable.
- •Signed written consent.
- •Medical approval for inclusion
排除标准
- •Heart disease.
- •Neurological patients.
- •Severe cognitive impairment in order not to complete the assessment.
结局指标
主要结局
Cognitive impairment
时间窗: Baseline
The cognitive impairment will be measured using the Montreal Cognitive Assessment. The Montreal Cognitive Assessment is a test designed as a rapid screening instrument for mild cognitive dysfunction. It assesses different cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation.
次要结局
- Sleep quality(Baseline)
- Activity monitoring(Baseline)
- Nutritional state(Baseline)
- Quality of life(Baseline)
- Cough(Baseline)
- Comorbidities(Baseline)
- Anxiety and depression(Baseline)
- Cognitive flexibility(Baseline)
- Forced vital capacity(Baseline)
- Forced expiratory volume in the first second(Baseline)
研究者
Marie Carmen Valenza
Assisstant professor
Universidad de Granada