Effect of Monosaccharides on Intestinal Barrier Function

Not Applicable

Completed

• Conditions: Endotoxemia; Dietary Habits

• Registration Number: NCT03482284
• Lead Sponsor: Prof. Dr. Ina Bergheim

Brief Summary

The aim of the present study is to determine the effect of monosaccharides on intestinal barrier function in healthy subjects.

Detailed Description

In the intervention study normal weight participants will receive defined amounts of monosaccharides for several days. Before and after intervention parameters of intestinal barrier function will be assessed.

Study Timeline

• Study Start: 2016-05-20
• Primary Completion: 2017-09-09
• Study First Submitted: 2018-03-20
• Study First Submitted QC: 2018-03-27
• Study First Posted: 2018-03-29
• Study Completion: 2018-08-01
• Status Verified: 2019-04
• Last Update Submitted: 2019-04-16
• Last Update Posted: 2019-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• BMI <25 kg/m2
• no kown history of metabolic disorders or fatty liver

Exclusion Criteria

• food allergies or intolerances (esp. fructose intolerance and malabsorption)
• renal insufficiency
• chronic disease of the gastrointestinal tract
• taking drugs affecting lipid or glucose metabolism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Changes in parameters of intestinal barrier function	1 week	Changes in endotoxin plasma levels

Secondary Outcome Measures

Name	Time	Method
Changes in blood pressure	1 week	Changes in systolic and diastolic blood pressure
Changes in markers for glucose metabolism	1 week	Changes in fasting glucose and fasting insulin levels
Changes in blood lipid levels	1 week	Changes in triglyceride levels
Changes in Uric Acid levels	1 week	Changes in Uric Acid blood levels