Low Dose St John's Wort for Depression
- Conditions
- Major Depression
- Registration Number
- NCT05477472
- Lead Sponsor
- Ceres Heilmittel AG
- Brief Summary
This observational study observes the routine use of low-dose St John's Wort herbal mother tincture in patients with major depression. It measures intensity of depression at the beginning of St Johns Wort and after 6 weeks and evaluates tolerability and compliance.
- Detailed Description
Herbal medicine is widely used, and high-quality evidence shows their efficacy and tolerability for specific disorders. Most of the studies, however, is conducted with standardized, relatively high dosed dry extract preparations, while other preparations such as tinctures are widely used as well. The aim of this observational study ist to document real-live use of the use of a low-dose herbal medicine preparation (a mother tincture) of St John's Wort (Hypericum perforatum), to compare depression intensity at the beginning and after 6 weeks of therapy using the Hamilton Depression Scale 17, and to evaluate tolerability and compliance. Finally, the results will be compared with results of randomized controlled trials examining high dosed dry extract preparations of St John's Wort for major depression.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
- diagnosis of mild or moderate depression according to ICD-10 or DSM-IV
- new start of CERES St John's wort mother tincture
- at the same time as St John's wort mother tincture started, other antidepressive therapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hamilton Depression Scale 17 Change at 6 weeks validated tool to measure depression intensity. Maximum score 51, minimum 0. Higher score means higher intensity of depressive symptoms.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CERES Heilmittel AG
🇨đź‡Kesswil, Thurgau, Switzerland