Attenuation of Pain in Men and Women

Not Applicable

Completed

• Conditions: Pain
• Interventions: Drug: Naltrexone, then placebo; Drug: Placebo, then Naltrexone

• Registration Number: NCT01220414
• Lead Sponsor: University of Wisconsin, Madison

Brief Summary

The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2010-09-28
• Study First Submitted QC: 2010-10-11
• Study First Posted: 2010-10-13
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Results First Submitted: 2015-12-07
• Status Verified: 2018-01
• Results First Submitted QC: 2018-01-22
• Last Update Submitted: 2018-01-22
• Results First Posted: 2018-02-19
• Last Update Posted: 2018-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Healthy men and women

Exclusion Criteria

• current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Women	Placebo, then Naltrexone	-
Men	Placebo, then Naltrexone	-
Women	Naltrexone, then placebo	-
Men	Naltrexone, then placebo	-

Primary Outcome Measures

Name	Time	Method
Time for Subject to Reach Pain Threshold	Baseline

Trial Locations

Locations (1)

University of Wisconsin-Madison; 🇺🇸 Madison, Wisconsin, United States