The Effect of Aging and Immobilisation on Muscle

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: 2 weeks of unilateral immobilisation and 4 weeks of resistance training

• Registration Number: NCT00559806
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

The debilitating effects of immobilisation on muscle strength and size in young individuals are well documented. Moreover, sarcopenia has long been recognized as a major cause of muscle strength loss in old age, however, changes in muscle mass and architecture with immobilisation in the elderly has not previously been investigated. This is contrasted by the fact that the elderly population more often undergoes periods of immobilization and disuse not only due to joint pain but also due to a higher degree of co morbidity and hospitalisation.The purpose of the present study was to compare the effect of a 2 week period of unilateral immobilisation on the physiological muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation angle in young and old healthy men.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study Completion: 2007-05
• Status Verified: 2007-11
• Study First Submitted: 2007-11-15
• Study First Submitted QC: 2007-11-15
• Last Update Submitted: 2007-11-15
• Study First Posted: 2007-11-16
• Last Update Posted: 2007-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Young healthy males (age 20-30 yrs)or old healthy males (age 60-80 yrs)

Exclusion Criteria

• Musculoskeletal disorder
• Diabetes
• Cardiovascular disease
• Neurological diseases; or
• Cognitive disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	2 weeks of unilateral immobilisation and 4 weeks of resistance training	11 healthy young males
1	2 weeks of unilateral immobilisation and 4 weeks of resistance training	9 healthy elderly males

Primary Outcome Measures

Name	Time	Method
muscle cross sectional area, maximal isometric muscle strength, specific force, muscle fascicle length and muscle fibre pennation	2 weeks of immobilisation and 4 weeks of resistance training

Secondary Outcome Measures

Name	Time	Method
single muscle fiber area, expression of myostatin and IGF-1 (RNA), changes in satellite activation and number	2 weeks of imm and 4 weeks of resistance training

Trial Locations

Locations (1)

Institute of Sports Medicine, Bispebjerg Hospital; 🇩🇰 Copenhagen, Denmark