A Continuation Protocol for Patients Previously Enrolled in a Study of Toca 511
Overview
- Phase
- Phase 1
- Intervention
- Toca 511 vector
- Conditions
- Glioblastoma Multiforme
- Sponsor
- Tocagen Inc.
- Enrollment
- 65
- Locations
- 11
- Primary Endpoint
- Long term safety follow up
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
This is a multicenter, open-label, continuation study to allow subjects who have previously received Toca 511 to continue to receive Toca FC and to allow for extended safety observations. Subjects will be seen on an every six week basis for 1 year or longer. Subjects who continue to receive Toca FC will receive the dose described in the "parent" protocol. If the Toca FC dose is adjusted for any reason, the serum concentration will be monitored. Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) scans will be performed as per standard of care.
If the subject has recurred/progressed, repeat intracranial injection of Toca 511 followed by Toca FC treatment may be offered to consenting patients.
Subjects who enter the study to continue Toca FC and subsequently discontinue Toca FC, and subjects who are only willing or able to perform limited testing will have viral testing alone, at the appropriate intervals.
After the first year, subjects will be seen twice yearly for the next 4 years and then contacted yearly for the next 10 years.
All subjects will be followed on study for at least 5 years regardless of whether they are taking Toca FC.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Informed Consent Form
- •Subject received Toca 511 in prior study.
- •Subject is willing to abide by protocol
Exclusion Criteria
- •Subject has history of allergy or intolerance to flucytosine
Arms & Interventions
Experimental
Single arm Toca 511 vector/5-FC prodrug
Intervention: Toca 511 vector
Experimental
Single arm Toca 511 vector/5-FC prodrug
Intervention: Toca FC • Flucytosine • 5-FC • 5-Fluorocytosine
Outcomes
Primary Outcomes
Long term safety follow up
Time Frame: From study entry up to 15 years
This will be based on treatment emergent adverse events, clinical laboratory values and viral testing.
Secondary Outcomes
- Overall survival in days from the initial Toca 511 administration on parent study to the date of death.(From initial Toca 511 administration to death of last patient alive for up to 15 years.)