Transcranial Direct Current Stimulation of the Primary Motor Cortex to Treat Levodopa-induced Dyskinesias
Not Applicable
Recruiting
- Conditions
- Parkinson Disease
- Interventions
- Device: Transcranial direct current stimulation
- Registration Number
- NCT05752240
- Brief Summary
The main objective of the study is to evaluate the efficacy of 10 sessions of transcranial direct current stimulation of the primary motor cortex to reduce levodopa-induced dyskinesia
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 32
Inclusion Criteria
- patients with diagnosis of idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria and levodopa-induced dyskinesia;
- age between 30 and 80 years;
- ongoing therapy with levodopa;
- fulfillment of requirements for the application of transcranial magnetic stimulation (TMS), assessed by completion of the TMS screening questionnaire.
Exclusion Criteria
- patients unable to give informed consent;
- cognitive impairment (MMSE ≤ 24);
- history of epilepsy;
- pregnant women.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Active stimulation Transcranial direct current stimulation Ten sessions of cathodic transcranial direct current stimulation over primary motor cortex Sham stimulation Transcranial direct current stimulation Ten sessions of sham stimulation over primary motor cortex
- Primary Outcome Measures
Name Time Method Reduction of dyskinesia 15 days Change in the total score of part III of the Unified Dyskinesia Rating Scale (range 0-112, 112 is the worse outcome) in on motor state at the assessment made three days after the end of treatment compared with the assessment made at baseline in the groups of patients treated with tDCS and sham-stimulation, respectively
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Flavia Torlizzi
🇮🇹Rome, Italy