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临床试验/NCT00985049
NCT00985049招募中不适用

Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

Brigham and Women's Hospital1 个研究点 分布在 1 个国家目标入组 350 人开始时间: 2009年3月最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
350
试验地点
1
主要终点
Differential gene expression

研究概览

简要总结

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Aged greater than 20 years
  • Undergoing aortic valve surgery with or without CABG surgery
  • Receive and apical vent as part of the surgery

排除标准

  • Will not receive an apical left ventricular vent

结局指标

主要结局

Differential gene expression

时间窗: Immediate

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jochen Daniel Muehlschlegel, MD

Associate Professor of Anesthesia

Brigham and Women's Hospital

研究点 (1)

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