Molecular Predictors of Lung Cancer Behavior: Controls
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy, no Evidence of Disease
- Sponsor
- Vanderbilt-Ingram Cancer Center
- Enrollment
- 37
- Locations
- 3
- Primary Endpoint
- Collection of biological specimens to use as controls in the study of lung cancer progression
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
RATIONALE: Studying samples of blood, urine, sputum, mouth cells, and bronchial tissue from healthy participants in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors learn more about the development of cancer.
PURPOSE: This laboratory study is looking for molecular markers in predicting lung cancer development using tissue samples from healthy participants.
Detailed Description
OBJECTIVES: * To obtain biological specimens from healthy participants with no known risk of lung cancer to use as controls in the study of lung cancer progression. * To identify new molecular abnormalities specific to the development of squamous cell carcinoma of the lung. OUTLINE: Serum, urine, sputum, and buccal cell samples are collected. Patients also undergo bronchoscopy for collection of bronchial tissue and bronchial brush samples. The samples are used for genomic and proteomic studies to identify new molecular abnormalities specific to the development of lung cancer.
Investigators
Pierre P. Massion, MD
Associate Professor of Medicine (Allergy, Pulmonary & Critical Care) and Cancer Biology; Pulmonary and Critical Care Medicine Doctor
Vanderbilt-Ingram Cancer Center
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Collection of biological specimens to use as controls in the study of lung cancer progression
Time Frame: Off study date, up to one year
Specimens are collected from healthy participants with no known risk of lung cancer
Secondary Outcomes
- Selection of important genes/proteins differentially expressed between study groups (e.g., normal vs low-grade vs high-grade vs invasive) and between normal smokers vs normal non-smokers(off-study date, up to one year)
- Identification of new molecular abnormalities specific to the development of squamous cell carcinoma of the lung(off-study date, up to one year)