A study on cutaneous resident memory T cell population in contact dermatitis and its correlation with the type of contact dermatitis, duration, severity and recurrence of the disease
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- comparison of memory T cell number(density) between lesional and normal skin in patients with contact dermatitis
研究概览
简要总结
This is a cross-sectional study wherein 26 consecutive patients clinically diagnosed as contact dermatitis satisfying the inclusion and exclusion criteria attending OPD of dermatology department of Amala Institute of Medical Sciences who consent for the study are selected. A detailed history will be taken and examination will be conducted. Under aseptic precaution and local anaesthesia 4mm punch biopsy will be taken from lesional and normal skin. Patients will be subjected to patch testing. The biopsy sections will be subjected to IHC staining for memory T cells using CD103 marker stain. Memory T cell population will be calculated by counting number of stained cells per 5 continuous high power field focused. Exploring more about cutaneous resident memory T cells and their role in the pathophysiology of contact dermatitis paves way for the development of various therapeutic options and thereby helping to prevent recurrences.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients clinically diagnosed with contact dermatitis by qualified dermatologists, who give consent to participate in the study.
排除标准
- •1.Patients with other skin diseases like psoriasis, vitiligo, cutaneous lupus erythematosus, alopecia areata, fixed drug eruption, melanoma, lichen planus 2.Patients with endogenous eczema 3.Patients who had taken systemic steroids, JAK inhibitors and immunomodulators in the past one month 4.Patients on topical steroids and topical calcineurin inhibitors for past 1 month 5.Patients who had undergone other modalities of treatment – Ayurveda/Homeopathy/Unani/Siddha in the past 1 month.
结局指标
主要结局
comparison of memory T cell number(density) between lesional and normal skin in patients with contact dermatitis
时间窗: at baseline
次要结局
- EASI score, Patch Test, comparing memory T cell number between type of contact dermatitis, duration, severity and recurrence of the disease(at the same time of sample collection)