KIRS-study: expression of inhibitory receptors on polymorphonuclear neutrophils during sepsis in childre

Completed

• Conditions: Blood poisoning; Sepsis; 10019815

• Registration Number: NL-OMON41281
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Sepsis patients: under age 12, diagnosed with severe paediatric sepsis or paediatric septic shock
Control group 1: patients under age 12, admitted to the ICU for a non-infectious, non-inflammatory illness
Control group 2: patients under age 12, undergoing elective cardiac catheterization.

Exclusion Criteria

Patients with any type of chronic infectious, inflammatory or autoimmune diseases
Patients after hematopoietic or solid organ transplantation
Patients receiving long term treatment with steroids or other immunosuppressive agents
Patients with an immunodeficiency
For control group 2: cyanotic heart disease

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Inhibitory receptor (SIRL-1 and LAIR-1)expression on blood neutrophils<br /><br>Disease severity as determined by the PRISM-III score, PELOD-2 score and<br /><br>Inotropic score</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>