RRR Study: study on the role of inhibitory receptors in respiratory syncytial virus (RSV) bronchiolitis

Withdrawn

• Conditions: bronchiolitis; luchtwegontsteking; 10047438

• Registration Number: NL-OMON34523
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Children under the age of 13 months that require mechanical ventilation for symptoms of respiratory syncytial virus (RSV) lower respiratory infection, known as the index group. In addition, 3 control populations will included: hospitalized RSV patients who do not require mechanical ventilation, ventilated control patients without infection and non-ventilated control patients without infection

Exclusion Criteria

Severe comorbidity, such as any organ dysfunction
Any Syndromal abnormality, such as Down Syndrome
Any other infection during past 14 days

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints: (1) expression of inhibitory receptors in<br /><br>peripheral blood and tracheal aspirate, (2) concentration of soluble inhibitory<br /><br>receptors in plasma, nasopharyngeal aspirates and urine. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A secondary objective is to study changes in bacterial carriership during the<br /><br>course of infection, which will be studied in nasopharyngeal swabs on admission<br /><br>and 1 month later.</p><br>