In-vivo multispectral optoacoustic imaging of thyroid nodules

Completed

Conditions: thyroid nodules
thyroid tumor
10014713

Registration Number: NL-OMON49819

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

1. Patients with thyroid nodules who underwent or will undergo an
ultrasonography (with TIRADS score) with FNA if indicated and will be scheduled
for a (hemi)thyroidectomy if indicated;
2. Age >= 18 years;
3. Written informed consent.

Exclusion Criteria

1. Medical or psychiatric conditions that compromise the patients' ability to
give informed consent;
2. Previous surgery in head and neck area on the ipsilateral side of the index
nodule
3. Previous radiotherapy in head and neck area
4. Pregnancy

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoint is quantification of the optoacoustic signal (HbO2,<br /><br>HbR, HbT, sO2, fat, water and collagen) observed by multispectral optoacoustic<br /><br>imaging using the MSOT Acuity Echo in vivo in patients with thyroid nodules,<br /><br>also in relation to the definitive pathology results (benign vs malignant).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- To explore a potential correlation between endogenous optoacoustic signals in<br /><br>vivo with cytology (the standard-of-care of Bethesda scoring system derived<br /><br>from FNA)<br /><br>- To explore a potential correlation between endogenous optoacoustic signals in<br /><br>vivo with TIRADS ultrasonography scoring system (the scoring system used by<br /><br>radiologists when evaluating the thyroid nodules with ultrasonography). </p><br>